The 16 Days of Activism take place from November 25, the International Day for the Elimination of Violence against Women, to December 10, Human Rights Day.

During the 16 Days of Activism against Gender-Based Violence, all Zonta clubs and districts are encouraged to take part in the Zonta Says NO to Violence Against Women campaign and to take local, national, and international actions to influence the making and implementation of laws, as well as changing gender-based attitudes and behaviors to end violence against women.